Please note that by default Royal Medical with compound Anastrozole / Arimidex into your testosterone. I would request that the two be separated prior to starting.
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Tesofensine is a serotonin-noradrenaline-dopamine reuptake inhibitor which was originally studied for its effect on Parkinson’s and Alzheimer’s. Unfortunately, its exploration for these indications were limited because the research subjects started losing too much weight. Since then, tesofensine has been studied as a way to treat obesity via its ability to reduce appetite. This molecular compound indirectly stimulates the cholinergic system and showed to be more successful than other weight loss agents. Tesofensine (TE) increases transmission of 3 monoaminergic neurotransmitters in the brain. These neurotransmitters are serotonin, norepinephrine, and dopamine which help regulate energy balance and are linked to obesity and depression. On average, its 6-month weight loss results from a phase 2b clinical trial resulted in a weight loss of around 25 pounds. TE research has shown a pronounced effect on appetite sensations and a slight effect on energy expenditure. Both effects can contribute to the strong weight reducing effect.
Tesofensine (also called TE) is a novel norepinephrine, dopamine, and serotonin reuptake inhibitor (triple reuptake inhibitor) that was initially developed for the treatment of neurodegenerative diseases like Parkinson’s disease and Alzheimer’s disease. As it turns out, the benefits of tesofensine extend further to include increased weight loss, even for people who do not undergo dietary changes. Tesofensine is now in phase III clinical trials as a weight loss aid.
What is Tesofensine?
Tesofensine is a member of the class of medications known as “triple reuptake inhibitors.” It prevents the presynaptic reuptake of neurotransmitters norepinephrine, dopamine, and serotonin. This leads to an increase in the effects of these neurotransmitters.
Tesofensine is a member of the phenyltropane class of drugs, which were originally developed to reduce cocaine dependency. In fact, this class of drugs arose as a result of efforts to disassociate the stimulant properties of cocaine from the factors that cause it to be addictive. In other words, the phenyltropane drugs are designed to stimulate the central nervous system without creating addiction.
It should come as no surprise, given their origins, that compounds like tesofensine have profound effects on neurotransmission, particularly dopamine, which is responsible for reward and craving behaviors. Research shows that tesofensine has no potential for recreational abuse, suggesting that at least some of the goals of efforts to dissociate the properties of certain stimulants have been achieved[1].
Given its ability to increase dopamine levels, tesofensine was originally developed for the treatment of Parkinson’s disease. During clinical trials, however, a significant “side effect” of weight loss was consistently noted. Because the compound proved to be inferior to existing medications in the treatment of neurodegenerative disease, but nearly twice as effective in promoting weight loss as any existing compound on the market, the decision was made to pivot to trials on weight loss[2].
The ability of tesofensine to increase levels of neurotransmitters in the brain does not directly account for its ability to increase satiety and feelings of fullness. Neither does this factor account for the hypothesized ability of tesofensine to alter energy balance and increase metabolism. At this point, the exact reason that tesofensine is such an effective weight loss agent remains unclear.
It was originally thought that tesofensine was a relatively balanced reuptake inhibitor, increasing levels of dopamine, norepinephrine, and serotonin in roughly equal proportions. This turns out to not be the case. After more extensive study, it was found that tesofensine is much more effective in boosting norepinephrine levels than serotonin levels. It is better at boosting both of those neurotransmitters than it is at boosting dopamine levels[3]. This difference may explain why the drug wasn’t particularly successful in the treatment of Parkinson’s disease.
Tesofensine activity is not, however, strictly limited to the neurotransmitters just described. Research shows that it is also an indirect potentiator of cholinergic neurotransmission. Of course, this is why the drug was originally of interest in Parkinson’s disease and suggests that its dopamine effects might be more nuanced than is currently understood. Tesofensine appears to promote cognition, learning, and memory via the cholinergic pathway. This pathway ultimately leads to increased BDNF levels in the brain[3]. BDNF stimulates neuron growth and has been shown in previous research to benefit people with depression, cognitive decline, and certain neurological conditions.
Tesofensine and Weight Loss
So, just how effective is tesofensine when it comes to weight loss? Phase IIB clinical trial results indicate that tesofensine produces about 12.8 kg (~28 pounds) of weight loss over six months when administered as a 1 mg dose to people who have a 300 kcal deficit in their diet. When compared to placebo, this is a 6-fold increase in weight loss[4]. Compared to currently available FDA-approved weight-loss medications, tesofensine is twice as effective. The average weight loss in all other clinical trials of currently available drugs was just 3-5 kg of reduction over 6 months. In other words, people lose twice as much weight with tesofensine as they do with any currently available weight-loss aid approved by the Food and Drug Administration.
Of course, it isn’t just the efficacy of tesofensine that makes it attractive as a weight loss agent. The compound is also easily administered by mouth just once per day. The side effect profile has also proved to be minimal in clinical trials, consisting mostly of dry mouth, headache, GI upset, and difficulty with sleeping. Both the dry mouth and difficulty sleeping show dose-dependent prevalence as well as attenuation over long-term use[4], [5]. So, it is possible to greatly mitigate these side effects by starting out on a low dose of tesofensine and then increasing it once attenuation has occurred.
Research shows that tesofensine produces the greatest weight loss when paired with dietary caloric restrictions and exercise. However, research shows that results can still be expected when tesofensine is taken and no differences in diet or exercise are encouraged. In one clinical trial, men treated with tesofensine lost weight despite the fact they were instructed to maintain their standard diet and levels of physical activity. These men lost 1.8 kg in two weeks when compared to placebo and reported higher feelings of satiety and fullness as well as decreased desire to eat. There was, additionally, evidence that men in the tesofensine arm of the study expended almost 5% more energy while they slept than those in the placebo arm. This correlates well with the additional finding that fat oxidation is increased by tesofensine[6].
One interesting aspect of tesofensine research in obesity has been the revelation that satiety appears to be centrally controlled and, perhaps, is harder to modify permanently than was once thought. The administration of tesofensine has a profound effect on satiety and hunger, thus greatly diminishing appetite. However, withdrawal of the drug, even after weight loss, results in an almost immediate return to baseline sensations. Reintroduction of tesofensine will suppress them again[7]. This suggests that appetite sensations are more permanent and ingrained than once thought and may, in fact, contribute to weight gain to a higher degree than once believe. In other words, it really isn’t a matter of willpower because some people are constantly being bombarded with signals that they are not full. Tesofensine is the first option to help quell those intrusive thoughts about hunger and the proof of its effectiveness is in the clinical trials showing significant weight loss.
In the past, it has been noted that compounds affecting appetite generally lose their efficacy over time. The same is true of tesofensine, with its ability to stave off hunger diminishing (but never completely stopping) with prolonged use. That said, tesofensine shows drastically longer-lasting hypophagic effects than other weight reduction aids and, more importantly, shows substantial rebound to baseline after a short holiday. In other words, a short break from tesofensine restores its ability to suppress appetite and hunger[9]. No trials have been carried out looking at the long-term weight loss of cycled tesofensine, but there is good reason to believe that the drug, when cycled appropriately, may produce even greater weight loss than what has currently been observed.
Research in rats indicates that tesofensine can help to improve glycemic control in a dose-dependent manner. In basic testing of glucose tolerance, tesofensine greatly attenuates the insulin response. This means less insulin is released in response to a sugar load. How could this contribute to weight loss though?
Insulin is a major cause of fat deposition. When there is too much sugar to store in the liver or muscle, insulin crams it into fat storage. This is why high glycemic index foods, like white breads, lead to higher levels of fat deposition. They flood the body with sugars which insulin simply clears as quickly as possible. By attenuating this effect, tesofensine helps to lower fat deposition even in the setting of high blood sugar[9].
It is also true that the accumulation of fat creates a kind of self-reinforcing spiral. Once fat is deposited, it influences insulin signaling in a number of different ways that lead to additional fat deposition. This additional deposition then further stimulates fat accumulation.
Even worse, fat has been shown to be a source of inflammation, particularly once a certain threshold is reached. This inflammation has been linked to everything from insulin resistance and the development of diabetes to heart disease and even neurodegenerative conditions. By breaking this cycle of fat deposition and increased inflammation, tesofensine is helping to shift the balance of metabolism and give the body a fighting chance against adiposity.
Tesofensine and Brain Health
Despite the abandonment of tesofensine in the treatment of neurodegenerative diseases, there is still good evidence that the compound has beneficial effects on cognition, memory, and neurogenesis. Though the dopamine boosting effects of tesofensine appear to be too small to be relevant in the treatment of Parkinson’s disease, there is still interest in using the peptide to improve cognitive function in other settings.
Research in rats shows that tesofensine boosts expression of brain derived neurotrophic factor and, as a result, increases neurogenesis in the rat hippocampus[3]. BDNF plays several roles in the brain including boosting cell survival and reproduction in addition to increasing synaptic transmission. Research shows that BDNF signaling is altered in a variety of disease conditions including depression, schizophrenia, obsessive-compulsive disorder, and Alzheimer’s disease among others. Unfortunately, research into the direct delivery of BDNF into the central nervous system of humans and animals has not shown any benefit in various neurodegenerative diseases. This suggests that the role of BDNF is more complicated than science has revealed to this point. There is likely to be future research looking at not just the ability of tesofensine to influence BDNF, but the impact that this has on brain function, structure, resilience to injury, and perhaps even our abilities to learn and remember.
A subcategory of brain health in which tesofensine may be helpful is depression. Research shows that exposure to stress can decrease BDNF levels in the brain and, if the exposure is prolonged, lead to atrophy of the hippocampus. This change in hippocampal structure has been directly linked to depression, especially major depression, and it is thought that existing treatments may be beneficial because they help to protect against or reverse these changes[10].
Tesofensine is known to improve BDNF levels and promote neurogenesis in the hippocampus, so it likely has anti-depressant properties. This, however, has not been the primary focus of research, as the compound was originally developed for its dopaminergic properties and then was discovered to have anti-obesity properties. All of that having been said, tesofensine offers a unique alternative to both anti-obesity and antidepressant applications because its properties cross both fields. It can be used as a standalone in either case, but the idea that it could have a “two birds with one stone” effect in the setting of weight loss and mood disorder is compelling[11]. This dual nature of tesofensine will likely make it a go to for people who struggle with weight and depression, two conditions that appear to have more than a few commonalities.
Tesofensine and Pain Management
The use of antidepressant medications in pain management is not new. Tri-cyclic antidepressants were among the first drugs available for treating mood disorders and have long been known to reduce nociception (pain perception), particularly in conditions like fibromyalgia. Research shows that the anti-nociceptive (anti-pain) properties of standard antidepressants, which affect only serotonin and norepinephrine, are enhanced by the addition of dopamine boosting agents[12]. Thus, there is speculation that triple reuptake inhibitors like tesofensine may provide benefits in pain management.
Tesofensine and Safety
Anti-obesity drugs have a long history of cardiovascular side effects. Fen-Phen is probably the most famous of the diet pills to have caused serious cardiac issues (e.g., heart valve damage) and though things have improved since 1997 when Fen-Phen was removed from the market, anti-obesity drugs are still hard on the heart. Sibutramine, for instance, has been associated with major cardiovascular events and was itself eventually withdrawn from the market in 2010[13]. The result is a death of options for treating obesity and feelings of hopelessness among those who seek relief. Phentermine, one of the ingredients in Fen-Phen can be used safely for short periods of time, but its reputation has produced fear and thus most people and healthcare providers are unwilling to use it.
To date, tesofensine has shown a substantially improved risk profile compared to other anti-obesity drugs. In particular, its central action on neurotransmitter reuptake as opposed to peripheral action of lipase inhibitors, amphetamines, and other compounds makes tesofensine unique[14]. There was some argument about trial design and whether side effects of tesofensine had been under reported[15]. The claim is that investigators did not list people with headache, migraine, stress, and depression prior to treatment as having those side effects if they experienced it during treatment. This is a valid criticism of the study design because a distinction should have been made between existing symptoms and new, but similar, symptoms. A change in trial design would likely have had no major impact on tesofensine side effect reporting.
Tesofensine Overview
Tesofensine is a novel inhibitor of the reuptake of serotonin, norepinephrine, and dopamine. By increasing levels of all three of these neurotransmitters, tesofensine increases BDNF expression patterns and promotes neurogenesis in the amygdala. None of this explains why it is the most effective weight loss agent developed to date, however. Research shows that tesofensine is at least twice as effective as any currently approved weight loss agent and with far fewer (and far less serious) side effects. While research is ongoing to get tesofensine to market as an anti-obesity drug, there is deeper research being carried out to understand how this molecule affects the sensations of hunger and satiety to produce weight loss. While tesofensine is proving to be a remarkable weight loss agent, it may yet prove to be even more remarkable by helping to elucidate the connection between the human brain and gut that controls eating behavior to begin with. With that knowledge, science could virtually eliminate obesity.
Tesofensine exhibits minimal side effects, good oral and excellent subcutaneous bioavailability in mice. Per kg dosage in mice does not scale to humans. Tesofensine for sale at Peptide Sciences is limited to educational and scientific research only, not for human consumption. Only buy Tesofensine if you are a licensed researcher.
The above literature was researched, edited and organized by Dr. E. Logan, M.D. Dr. E. Logan holds a doctorate degree from Case Western Reserve University School of Medicine and a B.S. in molecular biology.
Scientific Journal Author
Arne Astrup‘s major current research is focused on the role of dietary macronutrients and glycemic index for body weight regulation, and the hormonal mediation of hunger and satiety by gastrointestinal peptides such as GLP-1, PYY, CCK etc.. In addition, I head the OPUS Centre, ‘Optimal well-being, development and health for Danish children through a healthy New Nordic Diet’, which ran from 2009 until 2014. The main objective is to develop a healthy and palatable new food and eating concept, and to examine how such a diet can affect mental and physical health in a Nordic population. Other active research includes studies of the role of dairy and bio-active food ingredients (various specific fibres) in aspects of human health and testing of pharmaceutical compounds for the treatment of obesity.
Arne Astrup is being referenced as one of the leading scientists involved in the research and development of Tesofensine. In no way is this doctor/scientist endorsing or advocating the purchase, sale, or use of this product for any reason. There is no affiliation or relationship, implied or otherwise, between Peptide Sciences and this doctor. The purpose of citing the doctor is to acknowledge, recognize, and credit the exhaustive research and development efforts conducted by the scientists studying this peptide. Arne Astrup is listed in [2], [4], [7], and [15] under the referenced citations.
Semaglutide is a derivative of the naturally occurring GLP-1, a peptide known to lower blood sugar levels and enhance insulin secretion. Research shows that Semaglutide may also improve heart, liver, and lung function while helping to slow or prevent the effects of Alzheimer’s disease. Semaglutide has been shown to significantly decrease appetite by delaying gastric emptying and reducing intestinal motility. Glucagon-Like Peptide-1 (GLP-1) Analog Shown to Stimulate Insulin and Suppress Glucagon Secretion in a Glucose-Dependent Manner.
GLP-1, short for glucagon-like peptide-1 is a short, naturally occurring peptide hormone just 30-31 amino acids in length. Its primary physiologic function is to lower blood sugar levels by naturally enhancing insulin secretion. It also plays roles in protection beta cell insulin stores by promoting insulin gene transcription and has been linked with neurotrophic effects in the brain and central nervous system. In the GI system, GLP-1 has been shown to significantly decrease appetite by delaying gastric emptying and reducing intestinal motility. Preliminary research has shown impacts of GLP-1 in the heart, fat, muscles, bones, liver, lungs, and kidneys as well.
The primary focus of GLP-1 research has been in the realm of diabetes treatment/prevention as well as appetite suppression. Secondary research focuses on the potential cardiovascular benefits of the peptide. More recent, and thus less robust, research focuses on the ability of GLP-1 to stave off neurodegenerative disease. Though this latter area of research is newest, it is also the fast-growing area of GLP-1 study now that the peptide has been revealed to slow or prevent the accumulation of amyloid beta plaques in the setting of Alzheimer’s disease.
Perhaps the most important effect that GLP-1 has, according to Dr. Holst, is referred to as the “incretin effect.” Incretins are a group of metabolic hormones, released by the GI tract, that cause a decrease in blood glucose (sugar) levels. GLP-1 has been shown to be one of the two most important hormones (the other being GIP) to stimulate the incretin effect in rodent models. Though GIP circulates at levels roughly 10 times higher than that of GLP-1, there is evidence that GLP-1 is the more potent of the two molecules, particularly when levels of blood glucose are quite high.
A GLP-1 receptor has been identified on the surface of pancreatic beta cells, making it clear that GLP-1 directly stimulates the exocytosis of insulin from the pancreas. When combined with sulfonylurea drugs, GLP-1 has been shown to boost insulin secretion enough to cause mild hypoglycemia in up to 40% of subjects[1]. Of course, increased insulin secretion is associated with a number of trophic effects including increased protein synthesis, reduction in the breakdown of protein, and increased uptake of amino acids by skeletal muscle.
GLP-1 and Beta Cell Protection
Research in animal models suggests that GLP-1 can stimulate the growth and proliferation of pancreatic beta cells and that it may stimulate the differentiation of new beta cells form progenitors in the pancreatic duct epithelium. Research has also shown that GLP-1 inhibits beta cell apoptosis[1]. Taken in sum, these effects tip the usual balance of beta cell growth and death toward growth, suggesting that the peptide may be useful in treating diabetes and in protecting the pancreas against insult that harms beta cells.
In one particularly compelling trial, GLP-1 was shown to inhibit the death of beta cells caused by enhanced levels of inflammatory cytokines. In fact, mouse models of type 1 diabetes have revealed that GLP-1 protects islet cells from destruction and may, in fact, be a useful means of preventing onset of the type 1 diabetes[2].
GLP-1 and Appetite
Research in mouse models suggests that administration of GLP-1, and its similar cousin GLP-1, into the brains of mice can reduce the drive to eat and inhibit food intake[3]. It appears that GLP-1 may actually enhance feelings of satiety, helping individuals to feel fuller and reducing hunger indirectly. Recent clinical studies have shown in mice that twice daily administration of GLP-1 receptor agonists cause gradual, linear weight loss. Over a long period, this weight loss is associated with significant improvement in cardiovascular risk factors and a reduction in hemoglobin A1C levels, the latter of these being a proxy marker for the severity of diabetes and the quality of blood sugar control attained via treatment[4].
Potential Cardiovascular Benefits of GLP-1
It is now know that GLP-1 receptors are distributed throughout the heart and act to improve cardiac function in certain settings by boosting heart rate and reducing left ventricular end-diastolic pressure[5]. The latter may not seem like much, but increased LV end-diastolic pressure is associated with LV hypertrophy, cardiac remodeling, and eventual heart failure.
Recent evidence has even suggested that GLP-1 could play role in decreasing the overall damaged caused by a heart attack. It appears that the peptide improves cardiac muscle glucose uptake, thereby helping struggling ischemic heart muscle cells to get the nutrition they need to continue functioning and avoid programmed cell death. The increase in glucose uptake in these cells appears to independent of insulin[6].
Large infusions of GLP-1 into dogs have been shown to improve LV performance and reduce systemic vascular resistance. The latter effect can help to reduce blood pressure and ease strain on the heart as a result[7]. This, in turn, can help to reduce the long-term consequences of high blood pressure such as LV remodeling, vascular thickening, and heart failure. According to Dr. Holst, administration of GLP-1 following cardiac injury has “constantly increased myocardial performance both in experimental animal models and in patients.”
Size of damage in heart in control mice (A), mice given standard vasopressin therapy (B), and mice give GLP-1 (C).
There is some evidence to suggest that GLP-1 can improve learning and help to protect neurons against neurodegenerative diseases such as Alzheimer’s disease. In one study, GLP-1 was shown to enhance associative and spatial learning in mice and even to improve learning deficits in mice with specific gene defects. In rats that over-express the GLP-1 receptor in certain regions of the brain, learning and memory are both significantly better than in their normal controls[8].
Additional research in mice has shown that GLP-1 can help to protect against excitotoxic neuron damage, completely protecting rat models of neurodegeneration against glutamate-induced apoptosis. The peptide can even stimulate neurite outgrowth in cultured cells. Researchers are hopeful that additional research on GLP-1 will reveal how it might be used to halt or reverse certain neurodegenerative diseases[9].
Interestingly, GLP-1 and its analogue exendin-4 have been shown in mouse models to reduce levels of amyloid-beta in the brain as well as the beta-amyloid precursor protein found in neurons. Amyloid beta is the primary component of the plaques observed in Alzheimer’s disease, plaques which, while not necessarily known to be causative, are associated with the severity of the disease. It remains to be seen if preventing amyloid beta accumulation can protect against the effects of Alzheimer’s disease, but this research is, at the very least, a tantalizing clue as to how scientists my intervene in the progression of mild cognitive impairment to full Alzheimer’s disease[10].
GLP-1 exhibits minimal to moderate side effects, low oral and excellent subcutaneous bioavailability in mice. Per kg dosage in mice does not scale to humans. GLP-1 for sale at Peptide Sciences is limited to educational and scientific research only, not for human consumption. Only buy GLP-1 if you are a licensed researcher.
The above literature was researched, edited and organized by Dr. Logan, M.D. Dr. Logan holds a doctorate degree from Case Western Reserve University School of Medicine and a B.S. in molecular biology.
Scientific Journal Author
In 1986 Professor Jens Juul Holst discovered the GLP-1 hormone in connection with his work on stomach ulcer surgery. Since the discovery, Novo Nordisk have used the research to successfully develop products to treat diabetes and obesity. The hormone GLP-1 can be used to regulate blood sugar levels and satiety. Not only has it made treatment of obesity and diabetes possible, it has also proven useful preventatively through early diagnosis for citizens who are at risk of developing diabetes and obesity. In 2015, Jens Juul Holst received the prestigious international Fernström prize for his research on GLP-1. He is one of the most cited researchers in Europe, with over 1,200 published articles and citations in over 3,500 articles annually.
Professor Jens Juul Holst is being referenced as one of the leading scientists involved in the research and development of GLP-1. In no way is this doctor/scientist endorsing or advocating the purchase, sale, or use of this product for any reason. There is no affiliation or relationship, implied or otherwise, between Peptide Sciences and this doctor. The purpose of citing the doctor is to acknowledge, recognize, and credit the exhaustive research and development efforts conducted by the scientists studying this peptide. Professor Jens Juul Holst is listed in [11] under the referenced citations.
Referenced Citations
[1] “The Physiology of Glucagon-like Peptide 1 | Physiological Reviews.” [Online].
[2] “Combined treatment with lisofylline and exendin-4 reverses autoimmune diabetes. – PubMed – NCBI.” [Online].
[3] “The proglucagon-derived peptide, glucagon-like peptide-2, is a neurotransmitter involved in the regulation of food intake. – PubMed – NCBI.” [Online].
[4] “Interim analysis of the effects of exenatide treatment on A1C, weight and cardiovascular risk factors over 82 weeks in 314 overweight patients with… – PubMed – NCBI.” [Online].
[5] “Cardiac function in mice lacking the glucagon-like peptide-1 receptor. – PubMed – NCBI.” [Online].
[6] “Glucagon-like Peptide 1 Can Directly Protect the Heart Against Ischemia/Reperfusion Injury | Diabetes.” [Online].
[7] “Recombinant glucagon-like peptide-1 increases myocardial glucose uptake and improves left ventricular performance in conscious dogs with pacing-ind… – PubMed – NCBI.” [Online].
[8] “Glucagon-like peptide-1 receptor is involved in learning and neuroprotection. – PubMed – NCBI.” [Online].
[9] “Protection and reversal of excitotoxic neuronal damage by glucagon-like peptide-1 and exendin-4. – PubMed – NCBI.” [Online].
[11] Holst JJ. From the Incretin Concept and the Discovery of GLP-1 to Today’s Diabetes Therapy. Front Endocrinol (Lausanne). 2019;10:260. Published 2019 Apr 26. doi:10.3389/fendo.2019.00260 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497767/
are going to dinner and have some wine we’ll probably back by nine so should i take it at six should i take it at seven [Music] what’s going on guys tester levels here thanks for being here thanks for the support you guys are awesome if you’re new and you like content like trt supplements compounds medicine stuff like that click on the subscribe button if you like this video drop a like means a lot helps with the youtube algorithm now that we’re past 30 seconds we are talking about cyalis aka tadalafil which is an ed medication it’s long lasting it’s extremely popular it’s made the pharmaceutical industry over a billion dollars probably way more than that but it’s a pretty cool medicine and it actually has some additional benefits which is one of the reasons why i’m taking it i luckily do not have issues with ed i would let you know if i did in fact here’s a fun stat for you so if you’re 40 years old there’s probably a 40 chance that you’ve had encounters with ed 50 it jumps up to 50 60 60 percent it’s a real problem it’s caused by a lot of different things and this uh viagra viagra cialis actually does help so jump into kind of the history so tidal phil was approved for ed by the fda in 2003 five years after viagra so it’s kind of like viagra 2.0 um they both essentially do the same thing um but sialis lasts a lot longer so it’s it’s you’ll see from the slogan that they used to advertise it it’s kind of designed to where you take it and within 24-36 hours you should get some of the benefits if you need to the fda also later approved it for benign prostatic hyperplasia basically when the prostate gets enlarged tadalafil seems to help keep that in check and help kind of shrink the prostate a little bit so that’s pretty interesting that’s another benefit that it has and then the other one is that in 2009 they approved tadalafil for the treatment of pulmonary arterial hypertension aka high blood pressure so they’ve done studies and i’ll jump into one toward the end showing that taking this medicine does lower blood pressure so right there this medicine covers three things that are pretty important to men ed high blood pressure and a enlarged prostate so it’s a pretty cool medicine and it’s made a ridiculous amount of money but it’s actually a pretty good medicine and that’s also one of the reasons why lots of guys are taking it not necessarily for ed that’s the reason i’m taking it for blood pressure i’m only taking half the dose the typical dose is 20 milligrams i’m taking 10 a day and i will let you know kind of my experience with the main reason that a lot of guys do take this and it’s pretty interesting so if you’ve never tried it i’ve only been on it for 30 days i’ve never taken any type of ed medication before i actually have like 10 or 100 milligram viagras that i’ve never taken because i feel like i’m gonna i was gonna be that guy that had to call my doctor within four hours and that’s another thing with cialis and viagra you have to keep an eye out for if you do have an erection that lasts for longer than four hours it can cause damage to your boy it’s called priapism and they do have some medicine that’s kind of an antidote that kind of helps relieve the pressure and there’s also a medical procedure which you can guess is not probably not pleasant to go through so be safe obviously talk with your doctor about those side effects on the topic of side effects some of the common side effects for cyalis which i thought i was going to have and i wasn’t very happy about that is a headache muscle pain flushed skin and nausea and it can also cause priapism which we already covered don’t mess around with this i know it’s not fun to call your doctor and like you really have your doctor’s phone number like your doctor’s gonna pick up the phone and be like oh you’ve had an erection for three and a half hours and it’s starting to hurt okay well come meet me at the office no hell no they’re gonna tell you to go to urgent care or go to the emergency room so i don’t know i’m not recommending that you skip that step but your doctor is probably not coming to the office on the weekend to help you with your hard-on so there’s actually three different medicines that are approved to help treat ed tadalafil which is cialis sildenophil which is viagra and vardenafil i have no clue what the hell that one’s called but the way they work is they inhibit something called pde5 the inhibition of phosphodiesterase type 5 enhances erectile function by increasing the amount of cgmp however because sexual stimulation is required to initiate the local penile release of nitric oxide tadalafil’s inhibition of pde5 will have no effect without sexual stimulation so it’s i’m going to say i’m going to tell you kind of the real deal on this like so if i was looking at images of females on particular types of websites like normally it doesn’t have an effect down there for me you know i’m just kind of scrolling i’m clicking i’m looking you know but with with the sialis it it sometimes kind of goes to half staff if that’s a good way to put it so i mean i guess that would be considered stimulation because i am looking at images of females um but it definitely it makes a difference and i’ll go over like my full like results here toward the end but let’s get through all the scientific stuff so one of the huge benefits as i mentioned about cyalis is it’s half-life half-life’s about 17 and a half hours so that’s where they get that like up to 36 hours i guess they kind of round it up a little bit but so in theory 36 hours after you take a dosage of cialis you should have about 25 of that compound still in your body doing its thing so the idea behind it is you know i think viagra you have to use it within four hours so you know it’s tricky to say okay well all right six o’clock right now me and the wife are going to dinner and have some wine we’ll probably back by nine so should i take it at six should i take it at seven and then if we stay out later do i have to take another one so the idea behind this and it’s half life is attractive um is that you know i can that’s why they kind of call it the weekend pill the weekend you know ed med so you could take it on friday night and you know theoretically saturday sunday if the situation arises you can arise as well in 2004 lily pfizer glaxosmithkline spent a combined 373.1 million dollars advertising sialis viagra and levita respectively maybe lavrita is the vardenafo the slogan for sialis was when the moment is right you’ll be ready so once again going into that long half-life apparently they ran a commercial during the super bowl and then a lot of organizations and moms and stuff like that didn’t like that they were you know putting a dick pill advertisement in the super bowl either way big farmer made a lot of money and uh helped create a lot of boners so i have an excerpt from a study and i’ll put some stuff on the screen as i’m reading it kind of the results on the blood pressure side and it’s pretty pretty interesting this study proved that a single dose of tadala tadalophil 20 milligram results in a significant blood pressure reduction in subjects with hypertension these bp lowering effects are in keeping with other interaction studies in both hypertensive and coronary artery disease subjects taken as a whole these effects are clinically important as systolic blood pressure is recognized to be a major risk predictor in hypertension and is generally unsatisfactorily managed with only small proportions of patients reaching the target blood pressure so that’s why i’m taking cialis just to overall lower blood pressure i am kind of one of those people that gets a little anxious when they put the cuff on and i find myself like holding my breath and i have to like make myself breathe don’t ask why who the hell knows but my blood pressure does read a little bit higher i think resting um if i actually got one of those cuffs that fit my arm and i was just sitting on my couch just woke up i feel like it would be lower but in my opinion like any type of pressurized system like plumbing the more pressure you put into that system the more likely there is to be a leak a burst whatever so overall you know lowering your blood pressure a little bit i think is has some good health benefits and a lot of guys are doing the same thing i’ll run through my experience taking 10 milligrams of cialis per day the first day i took it and obviously i got it from my doctor and i’m just breaking the pills in half i’m not using an oil solution that you have to shake up or anything like that nothing janky but the first day i took it and about a few hours later i had a headache and i was like oh damn it i was like i’m one of those guys that’s going to get a headache from this and i’m not going to be able to take this medicine or just have to deal with headaches for the rest of my life luckily it was just a coincidence i haven’t gotten any headaches from it so far i’ve been on it for about 30 days now now in the bedroom um definitely feel a little bit more full um that’s uh yeah you you guys get it i don’t think i have to elaborate on that but it just feels more full more strong not that it was weak or you know halfway before i’ve always been lucky with that but definitely a little bit more full one of the more interesting things about it is that after i’m done you know with doing my thing it stays it stays in that position for like a few minutes so when you walk you know stand up go get a rag it’s it’s at attention so normally you know after you know it kind of goes back to its normal normal phase but it stays like that for longer now so it’s uh it’s an interesting thing um the only time i’ve ever been a little nervous about it is i did go to the nude beach and i wasn’t like thinking like oh if i see you know naked females that it’s just gonna randomly happen i was more worried about you know sometimes you get those random half chubs you know what i’m talking about but with this i feel like if i did get a random half chub there’s more of a chance of getting a full chub which is not ideal when you’re in a public situation i mean i don’t think i’d get kicked off or whatever else like that but um you know just something it didn’t happen but it was just something in my mind but now that i’m not really too worried about that anymore and i don’t really go to the beach too much as it is but overall i’m pretty happy with it um i haven’t like done like i haven’t formally gone and gotten my blood pressure yet um i don’t feel like my blood pressure is any lower not that i feel it you know anyway but i tried to go into one of those machines at the grocery store and of course it was broken um but overall i mean i think it’s it’s generally good medicine i mean i obviously we don’t know super long-term effects it is inhibiting pde5 they did mention that there’s other pdes different numbers like 3 and 11 and they said there’s no long-term studies on inhibiting pde-11 so they don’t really know i don’t know what the that does in the first place but there’s no studies on that and that apparently uh cyalis does inhibit pd 11 and i think viagra and vardena phil they inhibit some other ones as well as well as five but apparently five’s the penis one so so but anyway i think it’s pretty good medicine i mean i don’t have any prostate you know enlargement i luckily don’t have ed although i may encounter it at some point during my life and also studies showing that it’s lowered blood pressure i mean for me it’s a win-win-win um so just thought i’d let you know kind of how that you know everything about cialis hopefully you learned something found something interesting maybe start the conversation with your doctor maybe look around at different places you know in my description i don’t know i have lots of links for different stuff but anyway guys i hope you enjoyed the video if you did a like is always appreciated if you’re new click on the subscribe button but as always you’re awesome and get your levels tested
what if i told you you may be able to manage estrogen levels estrogen side effects while on trt naturally and without some of the nasty side effects of ais if i’ve got your attention stick around what’s going on guys welcome back to the channel thanks for being here thanks for the support you guys are awesome um i’m really excited to bring you this video i’ve been working on this for a long time and i think i found a really cool solution to managing estrogen levels without needing an ai you’re like oh well my doctor has me on an ai okay all right i’m not telling you to stop taking anything that your doctor prescribed you this is not medical advice i am not a doctor i’m not getting into the whole ai situation as to you know should you always take it should you never take it do only certain people need it long story short is if you’re watching this video there may be a good chance that you are taking anastrozole aka remedex to help block the conversion from testosterone to estrogen in your body now turning off a whole mechanism of your body that’s a whole other thing but what if i told you that there are some natural supplements that are derived from different fruits and vegetables that can help manage estrogen levels and also provide some health benefits it sounds like a win-win huh so i’ve been working on a formula of a combination of different herbs compounds that have been clinically shown to help with estrogen management and it’s called no ai and i’m pretty proud of this product i’m really excited to bring this to you um yes this is kind of like an advertisement for a product that i am selling on my website but i think that once you start seeing the ingredients some of the health benefits um and you’ve probably heard some of these if you’re in the trt like reddits and you know subreddits facebook groups you’ve heard of some of these herbs what i did was essentially combine five of them i think that this is going to be pretty big i mean this is the first product i have ever seen like this that is all natural that can help lower estrogen levels without the need of taking kind of toxic chemicals i mean i don’t think a remidex is going to kill you but it was developed for breast cancer and it has some nasty side effects so this website pretty much outlines like you know all the possible side effects and symptoms from taking aromadex and i know you know every medicine that is a prescription medicine has a laundry list of stuff like this and most people will not experience most of these if any at all it’s just the way medicine is there’s a couple that jumped out at me that i had never really looked at before weight gain joint bone or muscle pain mood changes depression difficulty falling asleep or staying asleep nervousness hair thinning and there’s two other things that arimadex has been shown to do you know it’s a breast cancer medicine so when doctors are evaluating okay you know are we going to give our patients something that could cause bone density loss you know losing you know your bone density which when you get older can be really bad and also has a negative effect on lipids which testosterone does as well so that’s a multiplier but when you’re looking at it any patient who has breast cancer you know hey what’s the most important critical thing we need to take care of right now we need to nuke this lady’s estrogen levels so that we can you know stop feeding this burst tumor so we’re not too worried about osteoporosis right now we’re not too worried about lipid levels you know we’re worried about keeping this person alive so that’s kind of the thing on arimidex you know like i said i don’t think it’s a medicine that’s going to poison you at trt levels to where your bones are just going to fall apart but it does have a negative lipid profile and then when you take testosterone which also has a negative lipid profile that is not ideal and that’s one of the reasons i really wanted to make this i always like to take the least amount of medicines possible and as well as herbal supplements that do have been shown to have health benefits so let’s jump in the first ingredient is one that’s most commonly used for men on trt it’s probably the first one that they see on a reddit uh you know post about you know natural estrogen management and it’s dim dendalyl methane and it’s basically derived and it comes from cruciferous vegetables like broccoli cabbage brussels sprouts cauliflower and you would need you need to eat two pounds of broccoli to get 20 milligrams of dim now dim doesn’t actually block the conversion from testosterone to estrogen in the body that’s what an aromatase inhibitor would do like arimidex what dim has been thought to do is help speed up your metabolism of estrogen in your body some research shows dim increases the level of favorable estrogens to hydroxy estrogen while reducing the levels of less favorable estrogen 6 hydroxy estrogen so you know dim it’s it’s like if you were eating lots of cruciferous vegetables you know they have lots of benefits some of the health benefits of dim helps prevent the effects of estrogen on cells slows some cancer cells lowers toxins produced by your body’s natural metabolism boosts antioxidants promotes weight loss enhances memory improves mood supports cardiovascular health promotes good muscle development improves prostate health for men so would you rather take a remodex or would you rather take them just for myself i would rather take them now uh the next one and i tried i felt had the most benefit for me um i have tried dim i personally like this one better um but why wouldn’t i combine the two and before i jump into the next one you know the dosages and i’ll put it on screen the dosages for these uh you know herbs in this formula they’re not like you know a quarter of what you would take they’re like full on dosages so where you buy each one of these supplements individually a it’ll cost you more and b you know you’ll see like the full like calcium d-glucarate one gram so you know it’s i didn’t skimp out on any of these ingredients and i actually made the formula pretty powerful to where i’m actually recommending that you start with half the dose start with two see how you feel if you still if you need to jump up to four but if you’d only need the two you’re good to go so let’s jump into calcium d-glucarate calcium d-glucate is the salt and and the commercial form of glucaric acid which occurs naturally in a variety of foods including apples oranges broccoli and spinach calcium diglucrate has been shown to speed up the process of removing toxins in the body in one study calcium d-glucate was able to reduce the number of estrogen receptors by 48 it has also been shown to lower serum estrogen levels by 23 percent it has but also been shown to reduce ldl levels which is of concern if you are on trt a pretty good profile right there what are some of the health benefits of calcium d-glucarate supports liver detoxification so for all you guys who like to drink every once in a while potentially inhibit some types of cancer that’s always a plus helps maintain already healthy cholesterol levels another concern on trt this next one here is an interesting one that not a lot of you guys have heard of and not a lot of people talk about in fact i don’t think i’ve ever seen anyone talk about this in a trt forum it is called indole-3-carbinol and it is also natural and comes from different vegetables indole-3-carbinol also known as i3c is formed from a substance called glucobrassonine found in vegetables such as broccoli brussels sprouts cabbage collards cauliflower kale mustard green turnips and rutabagas actually breaks down into dim in the body but not before helping to reduce estrogen and possibly having anti-cancer properties i3c has been shown to improve phase 1 detoxification of estrogens favoring the less potent 2oh estrone pathway i3c has been shown to exhibit potent anti-carcinogenic properties in a wide range of cancer such as lung liver colon cervical endometrial prostate and breast cancer sounds like pretty good stuff so once again all of these are in this formula kind of the way i thought about this was you know with like cycle sacs and i’m not getting into it but you don’t stack you know three things that have really high estrogenic you know conversions you know you stack something that really doesn’t convert you stack something else that does so you have a base so you’re kind of hitting it from you know multiple different angles so that was my thought process here and this is why i do think it’s going to be super effective but the next one is grape seed extract vitus vinifera 195 milligrams healthy dose grape seed extract is exactly what its name suggests it’s basically ground up grape seeds grape seed extract contains high levels of proscinition dimers that have been shown to be potent inhibitors of aromatase so this works in the same way as arimidex to where it actually kind of blocks the process of testosterone from converting into estrogen now do i think it’s as powerful as aromatics absolutely not i mean arumidex is a super powerful medicine you know like one milligram have you seen the caps or the pills they’re like this big one milligram is enough to like to drop your estrogen a lot you know when they’re doing breast cancer it’s one milligram a day that is a very potent medicine do i think that grape seed extract is you know as potent as arimidex absolutely not but in combination with these three other things i definitely feel like this pro this formula can help with your you know estrogen management move on to grape seed extract possible health benefits reduce blood pressure improve blood flow reduce oxidative damage improve collagen levels and bone strength the exact opposite of arimidex improve kidney function protect your liver enhance wound healing so i mean i’m not saying that you know this stuff all these four different compounds are you like you know you’re gonna feel like a completely new person and you know you’re not gonna get cancer and all this but overall studies have shown that you know in certain people these these compounds do good stuff and the last one and this really has nothing to do with estrogen um but it is actually a patented compound called bioperin black pepper piper negrum so this is actually a patented product uh it’s derived from black pepper but they’ve done it in some way extracted it made it super potent um that they’ve actually been able to patent this so bio parent is a patented highly concentrated black pepper extract containing at least 95 piperine in a form that is well absorbed by the body it has also been shown to increase the bioavailability of many natural compounds it is also a powerful antioxidant and has exhibited many health benefits they patent this stuff for a reason some of the possible health benefits improve metabolism raise dopamine and serotonin improve memory and cognition and improve immune system so as i stated this is not in here for estrogen management what this is in here for and this one is not a cheap ingredient because it’s patented but it is thought to help the bioavailability of many natural substances you’ll notice that it’s in a lot of different supplements it’s actually in greg ducette’s tercestrome builder turk builder it’s in there because he believes that it’s going to help the bioavailability of tercesterone speaking of tercastrone so because you guys follow me because you support me i’m put i put together a pretty badass special for you guys if you buy two of these these are 49.99 so it’s 100 bucks if you buy two of these i’m gonna give you free shipping shipping is not cheap these days because gas is expensive i will also and i have a coupon code that is it’s automatic so if you add two bottles of the no ai and you add either one of these the liquid tercestrone which my manufacturer says has a lot of bioavailability or the traditional capsules you’re going to get this for free so free these are both sixty dollars so you buy a hundred dollars worth of no ai hopefully get a lot of health benefits help manage your estrogen and then you can get another natural compound which a lot of people believe helps grow muscle so put that together for you um it seems like a pretty good deal on my end i’ll put that on the screen too just so you can see it yeah i don’t know you guys let me know what you think in the comments i mean i’m pretty happy with this formula i’ve never seen anyone put this together especially at these dosages and i think this is going to be pretty big let me know what you guys think if you do purchase it it’ll send you an email you know in like 30 days you can leave a review if you could definitely leave a review bad or good i want to hear the feedback i’m really freaking happy about this i i don’t like taking more medicines than i need to i think this is going to help and i think it’s going to improve people’s trt so that’s all i’ve got for you guys let me know in the comments what you think do you think that putting all five of these compounds together in one supplement i mean you can buy all this stuff you can buy each one of these compounds it’s gonna cost you more money and you’re gonna have to remember to take multiple pills instead of either taking one in the morning one in the evening or two in the morning two in the evening so this bottle could be a 30-day supply could be a 60-day supply just depends on how you respond to it but that’s all i’ve got for you guys let me know what you think in the comments i love you guys let me know your feedback i really want to know super interested thanks for being here and as always get your levels tested especially your estrogen
but so i was scrolling through like uh my google like article feed right and uh and it was like the headline was like new medicine can help uh you know help people lose weight and gain muscle and i’m like well that’s me right there i’m clicking on this i don’t care if it’s clickbait it may not be and so it actually it was it was an article on sarcopenic obesity is a condition that involves age-related muscle loss accompanied by obesity so it’s basically like you know as you get older you lose muscle mass that’s just the way it is and for a lot of people you know especially people that get heavier as they lose muscle mass they lose mobility they lose bone density they’re more prone to get injured stuff like that you know [ _ ] getting old and uh i was reading it a new study in mice has shown that a drug called bam 15 can prevent the loss of skeletal muscle mass and function and prevent weight gain and i was like oh [ _ ] and the study suggests that bam 15 achieved this by reducing inflammation and improving the function of mitochondria the power houses of cells and it went on to saying it has like an uncoupling effect and that reminded me of dnp which i’m not super familiar with but we had we’d mentioned bam 15 before it’s relatively new what is what is bam 15 so yeah that’s the fifteen is something that i would love to try if anybody wants to spend the sample uh but be interesting real expensive it is very very expensive uh but it may come down as like more and more people become aware of it it is a mitochondrial uncoupler so it’s very similar to dnp in that you aren’t increasing activity levels in terms of like being more active doing more cardio working out and you’re not changing your diet and you actually you’re like metabolic rate so like the rate you’re resting uh rate of which you burn calories right you’re you’re a dude that’s this fight that weighs this much is missing this much much less you burn so many calories just even at rest that metabolic rate actually increases so that you drop body fat with it um dmp has some peripheral effects right so if you’ve got like a sniper right you can just hit like one target but if you’re a shotgun you [ _ ] up a lot of stuff right because the spread of the shotgun what is that stuff in the shotgun right it like goes much wider okay well bam 15 is far more targeted like a sniper where dmp has these peripheral benefits so everybody knows about the the heat from dmp by the way dnp is probably gonna be my stack for cutting uh hypothetically right um but dmp has a thermogenic type of effect and it increases your body temperature drastically uh where there’s not just the uncoupling of the mitochondria to increase like the your metabolic rate like we talked about having a car in first gear so if you put your car in first gear and you’re driving 30 miles an hour you can hear the engine right because the revolutions per minute your rpm is up higher right because it’s needs in first gear you need to go and say 4 300 rpms just go 35 miles an hour we’re in second gear maybe you could do that at you know 2800 rpm or something so dnp increases that in your body so that it keeps up the engine because you just have more revolutions per minute with the mp where from my understanding with uh band 15 at least in the two studies that i looked at it did not have that effect it also has an awesome effect on your blood sugar levels right dope like this is such an awesome compound i would love to have this just like on deck to utilize every once in a while like maybe once or twice a year uh very positive effects of increasing your insulin sensitivity um like weight loss uh just just like awesome imagine stacking magic stacking bam 15 or dnp and siba glue tied right sigma glue time is the diabetes medicine yeah but you reduces your appetite so it’s approved from the fda for like a fat loss type of thing because it sinks your accident so oh yeah that’s another thing you could potentially test mmm interesting what you just said sarcopenic obesity involves a decline in energy expenditure instead of excess intake of calories so like you’re saying so this that obesity it’s slowing down the the the metabolic rate kind of how the body is naturally burning calories can you can you explain that again it says sarcopenic obesity involves a decline in energy expenditure instead of excess of calories thus treatments that could increase energy expenditure could help combat the disease so that’s what you’re just basically they’re just saying that’s like the opposite of what bam 15 does bam 15 is increasing that metabolic kind of rate of where you’re burning calories um blah blah blah they’ve already shown that band 15 a mitochondrial and coupling agent could prevent obesity in young mice maintaining a high fat diet the present study to aim to assess the ability of band 15 uh for older and aged mice um blah blah anyway long story short it worked yeah they lost body weight they lost body weight and gained muscle so that’s pretty impressive now what is bam 15 is it a peptide is it just a powder it’s a it’s a powder as far as i know but it’s just uh it’s actually a derivative of like dnp in some way where it doesn’t have like the structure of it like a chemical level is a little bit different so it doesn’t have so bad 15 does not create increase your body temperature like dnp does dnp also has a another like negative effect i think with your like electrolytes or something um be causing some type of issue there or something and band 15 doesn’t have that effect as well but what’s really cool well what’s really cool about medicine um and grant i’m not a huge fan of the pharmaceutical industry but what’s cool is you know like um even like like uh aromatase inhibitors and like serums like there’s like first generation that did what they needed to do but had side effects then you have generation two that’s a little more targeted and then you have generation three and i mentioned interested to see like the sixth and seventh generation like what’s the fifth generation of bam 15 like did they distill it even further down to where it has no side effects or nearly none and it’s three or four times more potent you know so that’s interesting and i think we’re just at the infancy of medicine and knowledge of the body um in general i mean what you’re i’m taking a note here to actually do a separate video on this because if you think about bam 15 positive effects in your lipids positive effects in your blood glucose positive effects on your insulin sensitivity positive effects on increasing your metabolic rate right and then you say stack that with say um a growth hormone korea guy right like mk677 hexavariant memorandum cjc or something and then something like a glp agonist like a very small dose of like the sigma blue type where it reduces your appetite like that could be a stupid cutting agent right because cemu glutathione reduces your appetite it also improves your blood glucose levels it also increases your insulin sensitivity like this could be a long time anything right because we talked about earlier sugar and like high blood sugar levels can have it’s associated with like five to ten different types of cancer right like this could be that’s and you’re talking about a cutting stack that has no stimulants in it i mean you can obviously add that in but that’s a non-stimulant that’s that’s interesting so so i guess i mean bam 15 sounds pretty freaking awesome and it sounds really good for the population so sure as [ _ ] isn’t going to get approved by the fda correct but the [ _ ] eye drops that grow your eyelashes and can like permanently blind you they prove that [ _ ] i’m like talking about this because like so i just updated my cycle and i’m getting excited about this because um i don’t have band 15 but i may or may not have some dnp for fertilizing my planks and um and i may or may not have seen blue tide um may or may not have something q677 so uh that might be because then i can reduce the dose of all of those right because if you put if you’re putting the total because i think about stacking like that right so if you’re gonna stack something the underground
thank you for being here thank you for support you guys are awesome if you’re new here and you’re into optimization trt supplements working out click on that subscribe button and if you do like this video a like is always appreciated so today we’re going to talk about ashwagandha and the reason i wanted to cover this is because it’s in almost every supplement sold that to raise your testosterone levels from like get roman there’s hundreds of them on the market and they all tell ashwagandha super raises your test levels you know anyway so i did want to do some research on it i honestly i found out a lot of stuff about ashwagandha that i never knew and it does seem like a really really good supplement but is it really really good for raising your testosterone levels is it going to get you from 300 to 900 well let’s jump in withania somnifera commonly known as ashwagandha or winter cherry or indian ginger or think it’s ginger is an important medicinal plant that has been used in indigenous medicine for more than 3 000 years some herbalists refer to ashwagandha as indian ginseng not ginger ginseng the plant extract has many bioactive compounds that exert antioxidant anti-inflammatory immunomodularity activities the plant extract and its bioactive compounds are used in the prevention and treatment of many diseases such as arthritis impotence amnesia anxiety cancer neurodegenerative and cardiovascular diseases and others sounds really good but but if you look at almost any supplement they look really good so but i’ll go through some more of the other benefits and then i’ll list some of the side effects and issues with it ashwagandha appears a promising safe and effective traditional medicine for managing schizophrenia conics chronic stress insomnia anxiety memory and cognitive enhancement obsessive-compulsive disorder rheumatoid arthritis type 2 diabetes and male infertility and bears fertility promotion activity in females a growth promoter activity in children and yeah so a lot of good stuff it has revitalizing action on the nerves bone marrow and reproductive organs regular consumption is believed to senescence which i have no idea what it is rectify abnormalities in the sense organs and hypotrophy of muscles rejuvenate the reproductive organs and increase fertility is also useful in stress weakness nervous exhaustion sexual debility geriatric problems memory loss muscular weakness insomnia and cough so it sounds really good and when i sat down to do research for this video i thought it was going to be a pretty quick video i was just going to look at a study or two about cortisol testosterone but there was a lot more to ashwagandha so that’s why this video is probably longer but here are some of the issues with ashwagandha and things you should look out before before you start taking it obviously always consult your doctor before taking any supplements and this is not medical advice i am not a medical professional so they did one study and they did show some liver injury and five patients that was associated with ashwagandha use liver function tests were elevated alt ast total bureau reuben and alkaline phosphate phosphatase so it may have some effect on your liver ashwagandha has been shown to alter thyroid function and increase thyroid hormones which could be dangerous for people with hyperthyroidism or an overactive thyroid it also could potentially interfere with thyroid tests ashwagandha can increase testosterone levels which could be dangerous for patients with prostate cancer if you have prostate cancer obviously i don’t think you should take something that supposedly can raise testosterone levels ashwagandha might increase drowsiness so the one of the things that they do say it can help with is sleep and we’ll look at a study here in a little bit but if you’re taking benzos barbiturates or alcohol you know it may it may increase that or you know have a multiplication effect on that so be careful with that ashwagandha is immunostimulating which means it boosts the immune system it’s just typically pretty good but um if you do have like an immunodisease or immuno what is it overactive immune system autoimmune that’s the word autoimmune it could it could make some of those medicines that you’re taking for that a little less effective so definitely keep that in mind and uh you know sown to lower blood sugar levels which is a good thing for most people but if you do have diabetes that’s something you should take into an account you know blood sugar levels are there for a reason why the did that just change i pulled some snippets from some studies on ashwagandha and there’s actually quite a lot of them so i’m going to run through that and then i’m going to look at cortisol anxiety sleep and then at the end testosterone levels so in a small study with 58 participants those who took 250 to 600 milligrams of ashwagandha extract for eight weeks had significantly reduced stress and levels of stress hormone cortisol so that’s one of the main things that people talk about with ashwagandha is cortisol and also the cortisol and testosterone ratio or you know how they interact with each other what’s more participants who took the ashwagandha supplements experienced significant improvements in sleep quality compared with the placebo group and we’re going to look at that that’s going to be a separate study as well another study in 60 people found that those who took 240 milligram extract for 60 days had significant reductions in anxiety compared to those who received placebo treatment pretty interesting one analysis of research included 12 studies in men and women who took ashwagandha between 120 and 1250 per day the results suggest the herb may enhance physical performance including strength and oxygen use during exercise that’s pretty interesting i want that in one study male participants who took 600 milligrams of ashwagandha per day and participated in the resistance trainings for eight weeks had significantly gathered grains gator great greater gains in muscle strength and size compared to the placebo group i also heard trend does that they found that participants who took a gram of ashwagandha extract daily for 12 weeks had greater reductions in depression and anxiety than those who took a placebo doesn’t sound bad study from 2012 stressed that adults who took 600 milligrams of ashwagandha for 60 days reported a 77 reduction in symptoms of depression while the placebo group sort of recorded a 5 reduction sounds pretty good like if that’s what i was looking at this i was like damn i didn’t realize ashwagandha had all these different benefits you know this is this one took me a while to do research on a review of 24 studies including five clinical studies and people with diabetes found the treatment with ashwagandha significantly reduce blood sugar hemoglobin a1c insulin blood lipids and oxidative stress markers like i was looking at this one i was like damn that sounds good that’s kind of like uh you know the same kind of idea with uh berberine and possibly curcumin turmeric in a study in 2008 adults experiencing stress took ashwagandha for 60 days as a result they had a significant reductions in c-reactive protein and inflammatory marker compared with those who consumed a placebo the video before this and i’ll put this on the screen i actually just got c-reactive protein done hemoglobin a1c homocysteine and an nmr lipid test so go watch that those are some really important tests to get done this was a study that they did a covid so they had a medicine that had a half a gram of ashwagandha and other herbs twice per day for seven days this reduced participants level of inflammatory markers yeah whatever those are compared with the placebo so that’s interesting a study in 50 adults ages 65 to 80 found that taking 600 milligrams of ashwagandha root per day for 12 weeks significantly improved their sleep quality and mental alertness upon waking up i want that i sleep like trash i have a hard time getting to sleep so let’s go to cortisol and this i’ll put this on screen here while i’m talking to you guys so this was a study that they did um one of the main studies that i found so they basically measured ashwagandha at 250 milligrams ashwagandha at 600 and a placebo and you see the baseline they both all these groups started at about 16 points whatever those are or 16 cortisol and then you can see with the 250 it drops down to 1474 and then at the end 1361 and then at the 600 uh started at 16 went down to 14.3 and then dropped down to 10.8 10.9 so that’s a pretty big reduction i mean that’s that’s a lot and then the placebo just went from 16.1 to 15.5 so that’s pretty significant that’s a significant drop compared to a placebo so i definitely do believe that it does lower your cortisol levels as with every supplement that i review and do on this channel now i have to go out and buy ashwagandha that’s just another pill i’m going to add to my stack which i’ll put a picture of on there it’s getting out of control it’s getting where i have to take like two handfuls at a time and free and jam these supplements but yeah it’s pretty interesting on cortisol so let’s jump over to an anxiety test and they did some you know they do some questionnaire that measures your anxiety levels so ashwagandha 250 everyone started at about 23 24 week four 250 dropped down to 21 and then down to 20 at the end um then 24 at 600 milligrams down to 22 down to 20. so it really wasn’t you know you take more ashwagandha you’re gonna have less anxiety doesn’t really seem to work like that and then in the placebo they drop down from 23 to 21 so it’s not a huge huge difference there but i mean it is it is somewhat you know looking like it can help with anxiety but it’s not like it doesn’t look like a massive amount so cortisol yeah 100 the anxiety i think your mileage may vary now this was interesting this one’s sleep and this one is pretty significant as well um so everyone started at about you know a little almost six let’s say uh 250 a day they dropped down to 4.95 down to 379. then uh in the 600 milligrams it dropped to 410 and then to 305 and now this is a quality like a quality of sleep thing so the lower the better you know 5 being bad one being fantastic and in the placebo uh week four drop down to five and then four point eight nine so that’s a big difference you know you know 3.05 3.79 to 489 that’s pretty significant that’s a that’s a good drop so once again if you’re having trouble sleeping this may be a supplement to look into so now let’s get into the testosterone one and you know this is the one this is why ashwagandha a bunch of guys are taking it lots of companies sell you know they sell supplements with ashwagandha in it and a bunch of other stuff like tong cataly boron stuff like that and they claim that they’re gonna raise your testosterone and as a guy if you’re not into this you’re not you don’t know about gear you don’t really know about trt or you don’t want to jump into this world sounds fantastic 60 for a month supply i can raise my testosterone frank thomas tells me that he’s a stud in bed and the ladies love him because of it so that’s why it’s so popular that’s why i wanted to do this video or one of the reasons ashwagandha treatment was associated with an 18 increase in dhea which is kind of a mother hormone a sex hormone involved in testosterone production participants who took the herb also had a 14.7 increase in testosterone than those who took the placebo so that sounds fantastic on paper 15 you know so if i’m at 300 that’s going to put me at what 345 that’s about there 345 15 jump so while 15 i mean that sounds fantastic on paper and marketing boosted testosterone levels 15 increases free testosterone but going from 300 to 345 it’s better but are you is that going to alleviate all your symptoms is that going to minimize the need for trt are all those other herbs going to jump you up to 900 probably not so actually i want to jump into a fertility aspect real quick i forgot this i put this out of order on my sheet here i’m a bad youtuber i’m telling you but a review of four studies found that ashwagandha treatment significantly increased sperm concentration semen volume and sperm motility in men with a low sperm count it also increased sperm concentration and motility in men with normal sperm count so that’s pretty solid i mean that’s i didn’t have numbers on that but that sounds pretty good another thing that can help increase semen volume is sunflower lecithin look it up it’s actually pretty cheap good supplement so let’s jump into this one so this one they did uh placebo and ashwagandha and they tested a few different hormones and this is interesting so we have the cortisol um so i’m kind of looking over here on the right placebo mean both periods and ashwagandha mean both periods i’m not sure exactly how they did this study but i think they jumped guys from a placebo to ashwagandha and then they had guys go from ashwagandha to placebo but i like this one here where they’re both on the same thing um so cortisol 29 uh then when ashwagandha 27. so good good statistical drop right there dhea went from 8.27 to 9.76 so pretty good solid junk and testosterone they went from 309.9 to 355 again as i was saying you know going from 309 to 355 that’s that’s good that’s good progress but like i said it’s not going to get you to 900 you know and if you do have a medical condition that is keeping your testosterone levels low whether your pituitary is not sending enough signal or your boys are not making enough of what you need you know i mean herbs can help to a point but it’s not gonna it’s not like you’re gonna if you go from 300 to 900 it’s just not reality i’m sorry they also tested estrogen which was kind of interesting you know so let’s see here so estrogen went from 23.95 to 21.18 so it’s a pretty good drop too nothing crazy but it’s a pretty decent drop so i mean that’s i was that was that something that you’d use as an ai i don’t think so um but overall i mean it seems to have a pretty good effect on on most of your hormones you know lowered cortisol raised dhea raised testosterone lowered estrogen so do i think ashwagandha is pretty good i do and i’m probably be adding it to my stack not for testosterone and not for estrogen i actually have a supplement called no ai i’ll put that on the screen it’s a blend of five different herbs that have been shown to help manage estrogen levels but i’m just going to take it for all the other benefits i mean it’s a pretty solid thing i mean our ancestors 3000 years ago you know they weren’t using it because it didn’t do anything they weren’t going out of their way to cultivate this herb prepare it chop it up and eat it because they didn’t feel any benefits at all so i think it’s a pretty solid herb one of some of the main side effects that i saw is essentially with most supplements diarrhea upset stomach kind of you know annoys your stomach but that’s about that’s about it you know of the normal ones that i saw there are some more rare ones that we saw earlier but what do you guys think about ashwagandha have you taken it have you taken a test booster you know have you noticed any difference do you think it’s complete garbage annoyed that you wasted time and you didn’t just hop on trt because you were trying to go this natural herb route let me know in the comments i’m interested to know but i’ve got to go guys i’ve got to go order some ashwagandha so that i can get into the 900s but as always guys you’re awesome love you guys thank you for the support and as always get your levels tested
what’s going on guys welcome to the test your levels youtube channel i’m tester levels thanks for being here you guys are awesome and as always thanks for the support today i have a pretty interesting study that just came out on clomid and it’s uh it’s pretty interesting we’re a little bit behind in research and some certain stuff clomid’s been around since like the 60s and we’re just now kind of looking at it from a like study perspective um you know as and for male you know hormones infertility stuff like that so uh pretty interesting and uh yeah let’s uh jump right in testosterone kinetics on hypogonadal men under clomiphene the objective to evaluate total testosterone kinetics and its predictors six months after the discontinuation of clomiphene citrate in patients with hypogonadism so essentially they’re giving these guys clomid and then seeing what happens six months after see where their testosterone levels are materials and methods consecutive patients with normal testicles and male hypogonadism designed by total testosterone under 300 nanograms per deciliter in the presence of signs or symptoms according to the previous consensus were prospectively evaluated in a urologic outpatient clinic by total testosterone at baseline after a daily dose of 50 milligrams of clomiphene citrate for 40 days and after the washout period of 6 months of clomiphene citrate discontinuation so first off that’s a pretty healthy dose of clomiphene you know typically when you’re doing 50 milligrams it’s typically every day clomiphene has a pretty uh long half-life and in this video i am not a big fan of clomid for the emotional side effects as well as it can mess with your vision and cause floaters i’m not a huge fan but i am a fan that i are doing at least studies on you know seeing different ways and how different medicines affect you know men’s testosterone levels i think that’s really important i think we’re just at like the beginning stages of this like in the grand scheme of things i’m not saying they haven’t done it before but i’m saying i think in the next 10 20 30 years they’re gonna find out a lot of stuff that we don’t know today but let’s move on results and it’s kind of a small study but still interesting among 75 patients the mean age of 57 testosterone at over 300 nanograms per deciliter was achieved by 69 or 92 percent of the men that’s pretty interesting in itself um so 32 of them or 42.6 got between 450 and 600 and then 27 or 36 got above 600. now here’s where it’s interesting 18 subjects 24 maintained asymptomatic testosterone levels over 300 nanograms per deciliter age negatively related to testosterone response blah blah predicts a median gain of 166.5 nanograms per deciliter at six months of discontinuation so this is where it’s interesting and i’ll go through the conclusions and then we can talk conclusions clomiphene is a compelling option to treat male hypogonadism although a chronic treatment is needed in most patients about one in four patients respond to clomid short trial to reboot the phil physiology wow that was painful further understanding the total testosterone kinetics in these patients in the long term is warranted so can clomid actually do like an hpta reboot you know there are certain things in the body that kind of get like reboot like rebooted like when you fast you know your gut biome kind of gets not replaced but you know things change and sometimes you know you can reset certain things in the body um you know something like ketamine kind of you know resets and rewires the brain so so can clomid you know like reboot your hpta i mean can it you know buy binding to the estrogen receptors making your brain think that you don’t have any estrogen you know sends the signal to kickstart the boys to produce more testosterone which will then convert over to estrogen you know that’s that whole feedback loop and i mean according to the study in 24 of men it can do some kind of reboot now if your your testicles cannot produce enough testosterone and your brain is just throwing signal at it or at them hopefully them i know some guys have had issues and that hurts my soul when i hear that but i mean you know you can’t just like you know if it’s even if it’s sending a crazy amount of signal i mean if they just aren’t up to the job i mean that’s like sending you know 500 emails to the lazy dude at the office and wondering why isn’t getting done you know what i’m saying so i just found this really interesting you know i mean i’m not a big fan of clomid um you know and if you don’t know clomid is a mixture of n-clomiphene and zuclomaphene n-clomiphene being a stand-alone medicine and what a lot of people are seeing is that you know it’s the enclosing is not as as much of what gives people side effects the vision side effects the you know emotional side effects but it does seem to to kick start your body’s natural production if you’re able to so i wonder if you know n clomiphene would if they did the same thing wouldn’t clomiphene you know do this exact same thing or is it the zooklomaphine because zooklomaphine has a longer half-life than n-clomiphene so would that make any difference in this if they did this study again within clomiphene another thing i would be interested in hearing is how many of these guys experience side effects and what side effects they experience taking 50 milligrams per day for 40 days like i said a healthy dose of clomid you know i mean hopefully they didn’t have any issues i’ve only taken clomid once it was as a post cycle alongside winstrol um i tell you guys this to show how stupid i was when i first started in this realm i uh i had done a cycle before i got big mostly probably water weight and then after i stopped i got bro right back to normal which is why i don’t really recommend cycles so for my next one i said well i’m going to do clomid for the post cycle therapy but i’m going to throw in winstrol so that i can keep some of my gains so i was essentially taking something to kick start my system as well as something suppressive at the exact same time so really freaking stupid i was probably like 20 something i didn’t know my ass for my elbow i see a lot of kids on the sarms forums they’re in the same boat and i’ve tried to tell some of them to you know some wise words from a 40 year old guy on trt but hey you know they’re kids they’re going to do what they need to do or want to do anyway thought you guys would find this interesting i mean i’m not recommending doing this protocol i would be interested to see study with n-clomiphene see if it does the same thing because it’s supposedly in theory causes less side effects but i thought you guys would find that interesting you know 24 one in four of guys that took 40 pills jumped up their testosterone levels by 166 and a half points pretty interesting but i’ll wrap up this video um as always you guys are awesome if you did like this video or found it interesting a like would be greatly appreciated if you like content like this and you’re just getting into the trt world or you’re a trt pro you can click on that subscribe button i got over 400 videos i also have links to all the stuff that i’m associated with uh but thanks for being here guys as always you’re awesome and get your levels tested
Testosterone Replacement Therapy Help 